Markus Thiersch
Leiter Molekulardiagnostik, Senior Researcher

Lehre und Vorlesungen (Auszug)

• 2022-heute: Animal experimentation and alternative methods in biomedical research (BME 311) für Masterstudenten in Biomedizin, Universität Zürich
• 2018-heute: Scientific Writing and Publishing (BME 410) ) für Masterstudenten in Biomedizin, Universität Zürich
• 2018/2022-heute: Physiologie Atmung und Blut für Vet. med. Studenten JK1 und JK2, Universität Zürich
• 2016-heute: Evolutionary Medicine: Human Adaptation (BIO 437) für Masterstudenten in Biologie, Universität Zürich
• 2013-heute: Veterinary Medicine: Comparative Morphology and Pathophysiology (BIO 409) für Masterstudenten in Biomedizin, Universität Zürich
• 2018-2019: Scientific Writing and Publishing an den slowakischen Universitäten Bratislava, Kosice und Martin
• 2015-heute: Betreuung von 10 Masterstudenten in Biomedizin und Veterinary Medicine, 3 Dr. med. vet. und 2 Ph.D. Studenten, und 3 Postdocs

Mitgliedschaften

• Mitglied des Zurich Center for Integrative Human Physiology (ZIHP)
• Mitglied Life Science Switzerland LS2

Preise

• 2014 Preis für bestes Poster an der «21. DVG Tagung der Fachgruppe Physiologie und Biochemie» in Zürich
• 2006 Travel Award für das 12. International Symposium on Retinal Degeneration 2006 in San Carlos de Bariloche, Argentina

Eingeworbene Forschungsmittel (Auszug)

• J & F Thoma Foundation, Zug, Switzerland (PI*):
  «Effect of Physical Exercise on Cancer Mortality in High Altitude Exposed Mice»
  10‘000 CHF
• Novartis Foundation for Medical-Biological Research, Basel, Switzerland (PI*):
  «Erythropoietin-independent role of the erythropoietin receptor in chemo- and radioresistance of lung cancers»
  60‘000 CHF
• J & F Thoma Foundation, Zug, Switzerland (PI*):
  «Effect of Physical Exercise on Cancer Mortality in High Altitude Exposed Mice»
  25‘000 CHF
• Vifor Pharma, Glattbrugg, Switzerland (PI*):
  «EPO resistant anemia in a spontaneously tumor-developing mouse model with iron deficiency»
  70‘000 CHF
• Marie-Louise von Muralt-Stiftung für Kleintiere, grant extension (PI*):
  «Analyzing the role of erythropoietin receptor in cancer growth and resistance to radiotherapy»
  30‘000 CHF
• Marie-Louise von Muralt-Stiftung für Kleintiere, project funding (Co-PI*):
  «The role of myoglobin in breast cancer: in vitro and in vivo models for analyses of incidence, proliferation, virulence and response to radiotherapy»
  140‘000 CHF

* PI = Principal Investigator

Publikationen (Auszug)

• Voluntary exercise does not always suppress lung cancer progression. Leimbacher AC, Villiger P, Desboeufs N, Aboouf MA, Nanni M, Armbruster J, Ademi H, Fluchter P, Ruetten M, Gantenbein F, Haider TJ, Gassmann M, Thiersch M. iScience. Aug 18 2023;26(8):107298. doi:10.1016/j.isci.2023.107298
• Association of serum hepcidin with prostatespecific antigen levels in men from high Andean cities of Peru. Alcantara-Zapata DE, Thiersch M, Gonzales GF. Int J Health Sci (Qassim). Mar-Apr 2023;17(2):28-36.
• Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice. Aboouf MA, Armbruster J, Guscetti F, Thiersch M, Boss A, Godecke A, Winning S, Padberg C, Fandrey J, Kristiansen G, Bicker A, Hankeln T, Gassmann M, Gorr TA. Sci Rep. May 9 2023;13(1):7530. doi:10.1038/s41598-023-34614-w.
• Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model. Bregolat NF, Ruetten M, Da Silva MC, Aboouf MA, Ademi H, Buren NV, Armbruster J, Stirn M, Altamura S, Marques O, Rodriguez JMM, Samillan VJ, Singh RP, Wielockx B, Muckenthaler MU, Gassmann M, Thiersch M. Haematologica. Apr 7 2022;doi:10.3324/haematol.2022.280732
• Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT. Aboouf MA, Guscetti F, von Büren N, Armbruster J, Ademi H, Ruetten M, Melendez-Rodriguez F, Rülicke T, Seymer A, Jacobs RA, Schneider Gasser EM, Aragones J, Neumann D, Gassmann M, Thiersch M. Frontiers in Oncology. 2022;Accepted: 18 Jul 2022doi:10.3389/fonc.2022.976961
• Pro-Apoptotic and Anti-Invasive Properties Underscore the Tumor- Suppressing Impact of Myoglobin on a Subset of Human Breast Cancer Cells. Aboouf MA, Armbruster J, Thiersch M, Guscetti F, Kristiansen G, Schraml P, Bicker A, Petry R, Hankeln T, Gassmann M, Gorr TA. Int J Mol Sci. Sep 29 2022;23(19)doi:10.3390/ijms231911483
• Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice. Jacobs RA, Aboouf MA, Koester-Hegmann C, Muttathukunnel P, Laouafa S, Arias-Reyes C, Thiersch M, Soliz J, Gassmann M, Schneider Gasser EM. Commun Biol. Aug 5 2021;4(1):938. doi:10.1038/s42003-021-02465-8
• Transcriptomic analysis of the mouse retina after acute and chronic normobaric and hypobaric hypoxia. Ebner LJA, Samardzija M, Storti F, Todorova V, Karademir D, Behr J, Simpson F, Thiersch M, Grimm C. Sci Rep. Aug 17 2021;11(1):16666. doi:10.1038/s41598-021-96150-9
• Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets. Aboouf MA, Armbruster J, Thiersch M, Gassmann M, Godecke A, Gnaiger E, Kristiansen G, Bicker A, Hankeln T, Zhu H, Gorr TA. Biochim Biophys Acta Mol Cell Biol Lipids. Dec 2021;1866(12):159026. doi:10.1016/j.bbalip.2021.159026
• SIron Regulation in Elderly Asian Elephants (Elephas maximus) Chronically Infected With Mycobacterium tuberculosis. Ruetten M, Steinmetz HW, Thiersch M, Kik M, Vaughan L, Altamura S, Muckenthaler MU, Gassmann M. Front Vet Sci. 2020;7:596379. doi:10.3389/fvets.2020.596379
• A Single 60.000 IU Dose of Erythropoietin Does Not Improve Short-Term Aerobic Exercise Performance in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial. • Haider T, Diaz V, Albert J, Alvarez-Sanchez M, Thiersch M, Maggiorini M, Hilty MP, Spengler CM, Gassmann M. Front Physiol. 2020;11:537389. doi:10.3389/fphys.2020.537389
• High-Altitude Cognitive Impairment Is Prevented by Enriched Environment Including Exercise via VEGF Signaling. Koester-Hegmann C, Bengoetxea H, Kosenkov D, Thiersch M, Haider T, Gassmann M, Schneider Gasser EM. Front Cell Neurosci. 2018;12:532. doi:10.3389/fncel.2018.00532
• Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. Maxwell P, Melendez-Rodriguez F, Matchett KB, Aragones J, Ben-Califa N, Jaekel H, Hengst L, Lindner H, Bernardini A, Brockmeier U, Fandrey J, Grunert F, Oster HS, Mittelman M, El-Tanani M, Thiersch M, Schneider Gasser EM, Gassmann M, Dangoor D, Cuthbert RJ, Irvine A, Jordan A, Lappin T, Thompson J, Neumann D. Br J Haematol. Feb 2015;168(3):429-42. doi:10.1111/bjh.13133

Bücher

• 2014 Grimm C., Wenzel A., Samardzija M., Thiersch M. (2007). Mechanisms of cell death and neuroprotection in retinal degenerationsIn: Brain and retina in degenerative diseases of childhood, by Schmitt B., Kohlschütter A., Neubauer B., Plecko-Startling B. (Edts.). SPS Verlagsgesellschaft, Heilbronn, Germany. pp 170-180.s

Vorträge (Auszug)

• 2023 LS2 Life Science Annual Meeting 2023, Switzerland
• 2022 8th Chronic Hypoxia Symposium 2023, La Paz, Bolivia
• 2022 DVG Fachgruppentagung Physiologie und Biochemie 2022
• 2022 Vetsuisse Bahnhofsevent
• 2020 16th Symposium of the Centre for Integrative Human Physiology in Zurich, Switzerland